BT-O2C

Overview

BT-O2C is a highly selective p300 PROTAC degrader. BT-O2C can significantly degrade the level of p300 in HAP1 cells. BT-O2C has significant cytotoxicity in CIC:DUX4 sarcoma (CDS) cell lines ( IC 50 ranges from 152 to 221 nM) and significantly reduces the expression of CDS target genes (ETV1, ETV4, ETV5) . BT-O2C can be used for research on cancer . (Pink: p300 ligand ( HY-174868 ); Blue: Cereblon ligand ( HY-W023573 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Histone Acetyltransferase | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > PROTACs

Product Information

• Catalog No.: HY-174866
• CAS No.: 3055107-34-8
• Molecular Formula: C48H48F5N9O8
• Molecular Weight: 973.94
• Purity: 99.31%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source