AY-4

Overview

AY-4 (Compound AY-4) is an efficient PROTAC degrader targeting FTH1 ( K d = 3.17 nM). AY-4 effectively upregulates the levels of ferrous (Fe 2+ ) and ferric (Fe 3+ ) ions in cells. AY-4 is a potential anticancer candidate compound that regulates iron homeostasis through ferritin degradation and enhances the efficacy of existing drugs. AY-4 can effectively reduce the level of FTH1 in breast cancer cells (Pink: FTH1 ligand AY-2 ( HY-174871 ); Blue: E3 ligand Pomalidomide ( HY-10984 ); Black: Linker, Pomalidomide -PEG3-acid ( HY-174872 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Ferroptosis

Product Information

• Catalog No.: HY-174867
• CAS No.: 3091513-13-9
• Molecular Formula: C41H59N7O10
• Molecular Weight: 809.95
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source