ITK-IN-6

Overview

ITK-IN-6 is a highly potent and selective ITK inhibitor ( K d = 387 nM). ITK-IN-6 directly binds to the ITK kinase domain. ITK-IN-6 blocks the release of pro-inflammatory cytokines and the activation and differentiation of Th2 and Th17 cells. ITK-IN-6 improves asthma progression by reducing inflammatory cell infiltration, mucus and IgE production. ITK-IN-6 significantly inhibits airway inflammation and is used in asthma research.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Itk

Product Information

• Catalog No.: HY-174903
• CAS No.: 2616666-32-9
• Molecular Formula: C20H16Cl2N2O4S
• Molecular Weight: 451.32
• Purity: 99.02%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.54 mM); Clear solution
• Availability: In-stock

Source

Original product source