NEP162

Overview

NEP162 is a BRD4 PROTAC degrader with DC 50 s of 1.2 and 1.6 μM in SW480 and U2OS cells. NEP162 exhibits antiproliferative activity, effectively inhibits tumor growth and induces apoptosis . NEP162 can be used for the study of osteosarcoma, colorectal cancer and non-small cell lung cancer , etc. (Pink: BRD4 ligand : ( HY-78695 ), Blue: E3 ligase Ligand ( HY-D2259 ), BLACK: Linker, E3 ligase ligand-linker conjugate ( HY-174997 )). (Pink: BRD4 ligand ( HY-78695 ); Blue: Ligands for E3 Ligase ligand ( HY-D2259 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epigenetic Reader Domain | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-174996
• CAS No.: 3031840-36-2
• Molecular Formula: C50H56ClN11O3S
• Molecular Weight: 926.57
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source