CDK6/9-IN-2

Overview

CDK6/9-IN-2 is a highly active dual inhibitor of CDK6 ( IC 50 = 15 nM) and CDK9 ( IC 50 = 22 nM). CDK6/9-IN-2 is selective for CDK2 , CDK8 , and CDK11 . CDK6/9-IN-2 inhibits the proliferation of HaCaT cells induced by IFN-γ / TNF-α and suppresses the STAT3 pathway and the expression of inflammatory factors. CDK6/9-IN-2 can alleviate psoriatic dermatitis and is useful in psoriasis research.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > CDK | Products > Signaling Pathways > STAT | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-175013
• CAS No.: 3068529-24-5
• Molecular Formula: C25H30ClN7O
• Molecular Weight: 480.01
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source