PROTAC IRAK4 degrader-13

Overview

PROTAC IRAK4 degrader-13 (Degrader 1) is a selective IRAK4 PROTAC degrader with DC 50 s of 0.86 and 1.1 nM for monocytes and lymphocytes in PBMCs, respectively. PROTAC IRAK4 degrader-13 significantly induces TIR signal activation, and inhibits the expression of circulating proinflammatory cytokines in Imiquimod ( HY-B0180 ) induced psoriasis mice model. PROTAC IRAK4 degrader-13 can be used for TLR - and IL-1R -driven driven neutrophilic inflammation diseases like hidradenitis suppurativa (HS) and atopic dermatitis (AD) research. Pink: IRAK4 ligand; Blue: E3 ligase ligand; Black: linker

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > IRAK | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-175022
• CAS No.: 2432992-21-5
• Molecular Formula: C44H52F3N9O5
• Molecular Weight: 843.94
• Purity: 99.58%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.96 mM); Clear solution
• Availability: In-stock

Source

Original product source