RIPK2-IN-8

Overview

RIPK2-IN-8 is an orally active and highly selective RIPK2 inhibitor ( IC 50 = 11 nM). RIPK2-IN-8 is highly selective for RIPK2 over RIPK1 ( IC 50 > 30,000 nM) and has a moderate inhibitory effect on RIPK3 ( IC 50 = 44.61 nM). RIPK2-IN-8 inhibits the NOD2- RIPK2 signaling pathway and the expression of the inflammatory cytokines IL-6 and TNFα, thereby exerting anti-inflammatory effects. RIPK2-IN-8 has demonstrated anti-inflammatory and hepatoprotective effects in an acute liver injury (ALI) model and can be used in ALI research.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > RIP kinase | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-175026
• CAS No.: 3036254-29-9
• Molecular Formula: C22H20FN5OS2
• Molecular Weight: 453.56
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source