Itraconazole

Overview

Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC 50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase ( cytochrome P450 enzyme ), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein ( OSBP ) inhibitor.

Application

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Product Information

• Catalog No.: HY-17514
• CAS No.: 84625-61-6
• Molecular Formula: C35H38Cl2N8O4
• Molecular Weight: 705.63
• Purity: 99.59%
• Storage: 4°C, protect from light * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
• Solubility: ≥ 0.62 mg/mL (0.88 mM); Clear solution
• Availability: In-stock

Source

Original product source