GL64

Overview

GL64 is a selective agonist of ADGRD1 ( EC 50 = 3.98 μM). GL64 has low selectivity for ADGRD2, ADGRG5, ADGRG6, CELSR1, CELSR2, CELSR3, and ADGRG4 isoforms. GL64 activates ADGRD1 by mimicking the satchel sequence. GL64 regulates osteoclast maturation through the cAMP-PKA-NFATC1 pathway. GL64 effectively inhibits osteoclastogenesis and prevents bone loss both in vitro and in vivo. GL64 is useful in the study of osteoclast-related diseases.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Endocrinology | Products > Signaling Pathways > Nuclear Factor of activated T Cells (NFAT)

Product Information

• Catalog No.: HY-175232
• CAS No.: 488801-10-1
• Molecular Formula: C27H19Cl3N2O2
• Molecular Weight: 509.81
• Purity: 98.80%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source