MI891

Overview

MI891 is a highly selective PXR antagonist ( IC 50 = 3.76 μM, K d = 1.7 μM) and inverse agonist ( IC 50 = 6.1 μM). MI891 selectively disrupts the interaction between PXR and its coactivator SRC1. MI891 effectively inhibits Rifampicin ( HY-B0272 )-induced PXR activation. MI891 is useful for the study of metabolic diseases and other diseases .

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > Pregnane X Receptor (PXR) | Products > Signaling Pathways > Cytochrome P450

Product Information

• Catalog No.: HY-175264
• CAS No.: 2530027-77-9
• Molecular Formula: C23H14Cl2F2N6O
• Molecular Weight: 499.30
• Purity: 99.90%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source