URAT1-IN-14 is a potent and orally active Urate transporter 1 ( URAT1 ) inhibitor. URAT1-IN-14 inhibits the human URAT1 in HEK293 cells with an IC 50 of 0.72 μM. URAT1-IN-14 exhibits low cytotoxic in Hep-G2 cells. URAT1-IN-14 shows urate-lowering effect in hyperuricemia mouse models. URAT1-IN-14 can be used for the study of hyperuricemia and gout.
Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > URAT1
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