Kv7.2/Kv7.3 activator-3

Overview

Kv7.2/Kv7.3 activator-3 (GRT-X) is an orally active Kv7.2 / Kv7.3 and TSPO activator. Kv7.2/Kv7.3 activator-3 activates Kv7.2 / Kv7.3 , Kv7.4 , and Kv7.5 with EC 50 values of 0.37, 2.06, and 0.75 μM, respectively, and binds to TSPO with K i values of 0.07 μM (rat membrane) and 4.60 μM (human U-118 MG cells). Kv7.2/Kv7.3 activator-3 prevents motor neuron degeneration in mice and humans conditioned by ALS/FTD astrocytes. Kv7.2/Kv7.3 activator-3 stimulates dorsal root ganglion axonal growth through TSPO and K v7.2 / 3 activation. Kv7.2/Kv7.3 activator-3 has anti-epileptic effects in epileptic seizure models. Kv7.2/Kv7.3 activator-3 reduces pain hypersensitivity in patients with diabetic neuropathy, promotes neuronal survival and regeneration after cervical neuropathy in rats, and accelerates the recovery of normal function of sensory and motor neurons.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Potassium Channel | Products > Signaling Pathways > TSPO

Product Information

• Catalog No.: HY-175340
• CAS No.: 1361107-81-4
• Molecular Formula: C22H20F4N2O3
• Molecular Weight: 436.40
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source