DeFer-2

Overview

DeFer-2 is a ferritin PROTAC degrader ( K d = 17.1 μM). DeFer-2 induces ferritin degradation, triggering caspase 3 -GSDME-mediated pyroptosis in cancer cells through free iron accumulation and elevated ROS . DeFer-2 significantly inhibits tumor growth and prolongs survival in mice bearing B16F10 subcutaneous tumors. DeFer-2 can be used to study melanoma. (Pink: Ferritin ligand ( HY-N1446 ); Blue: VHL ligand ( HY-125845 ); Black: linker ( HY-N0067 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Pyroptosis | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-175381
• CAS No.: 3058911-16-0
• Molecular Formula: C44H69N5O5S
• Molecular Weight: 780.11
• Purity: 98.25%
• Storage: -20°C, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (3.20 mM); Clear solution
• Availability: In-stock

Source

Original product source