PROTAC sEH degrader-3

Overview

PROTAC sEH degrader-3 (Compound 1a) is a targeted sEH PROTAC degrader that can selectively degrade sEH in the cytosol without affecting sEH in peroxisomes. PROTAC sEH degrader-3 degrades sEH through a CRBN -dependent lysosomal pathway rather than the proteasome , with an IC 50 of 0.8 nM against hsEH . PROTAC sEH degrader-3 can inhibit endoplasmic reticulum stress and can be used in the research of inflammation, metabolic diseases, and other diseases related to endoplasmic reticulum stress. (Pink: sEH ligand ( HY-114266 ); Blue: Cereblon ligand ( HY-14658 ); Black: linker ( HY-W008352 )).

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Epoxide Hydrolase

Product Information

• Catalog No.: HY-175392
• CAS No.: 3093413-94-3
• Molecular Formula: C46H53F3N6O14
• Molecular Weight: 970.94
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source