Yoda2

Overview

Yoda2 (KC289), the potassium salt of Yoda1 ( HY-18723 ), is a PIEZO1 agonist with an EC 50 of 150 nM. Yoda2 evokes Ca 2+ elevation and NO-dependent relaxation. Yoda2 induces relaxation in mouse arterial and cavernous tissues. Yoda2 inhibits glucocorticoid-induced osteoclast formation and bone resorptive activity, reverses glucocorticoid-induced bone density loss and architectural deterioration, and does not induce medication-related osteonecrosis of the jaw in mice. Yoda2 can be used for the researches of hypertension and osteoporosis.

Application

Products | Products > Disease Areas > Hypertension | Products > Disease Areas > Osteoporosis | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Cardiovascular Disease | Products > Disease Areas > Mineral Metabolism | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cardiovascular Disease | Products > Signaling Pathways > Piezo Channel | Products > Signaling Pathways > Calcium Channel

Product Information

• Catalog No.: HY-175416
• CAS No.: 3081450-95-2
• Molecular Formula: C16H9Cl2KN2O2S2
• Molecular Weight: 435.39
• Purity: 99.57%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution
• Availability: In-stock

Source

Original product source