MLS6357

Overview

MLS6357 is a D3 dopamine receptor (D3R)-selective positive allosteric modulator (PAM)-antagonist. MLS6357 exhibits antagonist activity in the D3R-mediated and the BRET-based β-arrestin recruitment assay with IC 50 s of 13 and 14 μM, and no activity for other DAR subtypes (D1R/D2R/D4R/D5R) ( IC 50 > 100 μM). MLS6357 is also an antagonist in the D3R-mediated Go-BRET assay with an IC 50 of 17 μM. MLS6357 can be used for the study of neuropsychiatric disorders, including substance use disorder.

Application

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Product Information

• Catalog No.: HY-175504
• CAS No.: 932544-59-7
• Molecular Formula: C18H22ClN3O3S
• Molecular Weight: 395.90
• Purity: 99.57%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 5 mg/mL (12.63 mM); Clear solution
• Availability: In-stock

Source

Original product source