TREM2 agonist-5

Overview

TREM2 agonist-5 is the microglial lipid-sensing receptor ( TREM2 ) agonist with a K d of 71.36 μM. TREM2 agonist-5 is a racemic structural analog of the TREM2 agonist VG-3927 and exhibits superior microglial phagocytosis and activates TREM2 signaling in HEK293-hTREM2/DAP12 cells. TREM2 agonist-5 displays a superior in vitro pharmacokinetic profile to VG-3927. TREM2 agonist-5 can used for the study of Alzheimer’s disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Alzheimer's Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > TREM receptor

Product Information

• Catalog No.: HY-175510
• CAS No.: 3114105-24-4
• Molecular Formula: C24H21ClFN5O
• Molecular Weight: 449.91
• Purity: 99.61%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (5.56 mM); Clear solution
• Availability: In-stock

Source

Original product source