TQ-3959

Overview

TQ-3959 is an orally active BTK PROTAC degrader, with a DC 50 of 14.6 nM. TQ-3959 exerts antiproliferative activity against both wild-type BTK and C481S mutant BTK cell lines. TQ-3959 exhibits tumor growth inhibition in female NOD-SCID mice bearing TMD-8 xenografts. TQ-3959 can be used in the research on B-cell malignancies such as lymphoma. (Pink: Btk ligand ( HY-175543 ); Blue: Cereblon ligand ( HY-W733888 ); Black: linker ( HY-W061884 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Btk

Product Information

• Catalog No.: HY-175541
• CAS No.: 2926610-43-5
• Molecular Formula: C40H47N11O5
• Molecular Weight: 761.87
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source