ITGB3-IN-1 is an orally active integrin subunit beta 3 ITGB3 inhibitor with a K d of 7.26 μM. ITGB3-IN-1 exhibits potent anti-orthopoxvirus effects with an EC 50 for vaccinia virus (VACV) of 1.82 μM. ITGB3-IN-1 inhibits hERG with an IC 50 of 1.13 μM. ITGB3-IN-1 can be used for the study of orthopoxvirus .
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