NLRP3/URAT1-IN-1

Overview

NLRP3/URAT1-IN-1 is an orally active double inhibitor of NLRP3 and URAT1 ( IC 50 = 3.81 μM). NLRP3/URAT1-IN-1 inhibits IL-1β release in LPS ( HY-D1056 ) and ATP-stimulated mouse bone marrow-derived macrophages (BMDMs), with an IC 50 of 2.61 μM. NLRP3/URAT1-IN-1 reduces serum uric acid (SUA) and alleviates liver/kidney damage in mice with acute hyperuricemia (HUA). NLRP3/URAT1-IN-1can be used for the study of gout and hyperuricemia.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Metabolic Disease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > NOD-like Receptor (NLR) | Products > Signaling Pathways > URAT1 | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > OAT | Products > Signaling Pathways > GLUT

Product Information

• Catalog No.: HY-175645
• CAS No.: 2994637-53-3
• Molecular Formula: C24H17BrN2O3S2
• Molecular Weight: 525.44
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source