STAT6-IN-9 is a potent STAT6 inhibitor with an EC 50 value of 4 nM. STAT6-IN-9 effectively blocks STAT6 activation mediated by the IL-13 -IL-13 receptor/ IL-4 receptor pathway. STAT6-IN-9 inhibits CCL17 secretion with an IC 50 value of 4.6 nM. STAT6-IN-9 can be used to investigate various chronic inflammatory diseases mediated by STAT6 , such as allergy, asthma, and chronic obstructive pulmonary disease.
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