IID432

Overview

IID432 is a potent, orally active, and covalent inhibitor of Trypanosoma cruzi topoisomerase II . IID432 shows an EC 50 of 8 nM against T. cruzi intracellular amastigotes, exhibits excellent oral bioavailability (52% in rats), favorable ADME properties, and no S1P pathway modulation. IID432 achieves relapse-free cure in a chronic T. cruzi infection mouse model, can be used for the study of Chagas disease.

Application

Products | Products > Disease Areas > Infection | Products > Disease Areas > Parasitic Infection | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Anti-infection | Products > Research Areas > Infection | Products > Signaling Pathways > Topoisomerase | Products > Signaling Pathways > Parasite

Product Information

• Catalog No.: HY-175741
• CAS No.: 3094992-69-2
• Molecular Formula: C19H19N7O
• Molecular Weight: 361.40
• Purity: 99.98%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source