SMARCA2/4 degrader-1

Overview

SMARCA2/4 degrader-1 is a SMARCA2/4 molecular glue degrader with a DCAF16 EC 50 of 110 nM. SMARCA2/4 degrader-1 covalently adducts at cysteine to form a ternary complex with SMARCA2/4 and recruits CUL4 DCAF16 and CRL1 FBXO22 E3 ligase complexes. SMARCA2/4 degrader-1 induces ubiquitination and proteasomal degradation of SMARCA2/4. SMARCA2/4 degrader-1 can be used for research of SMARCA4-deficient malignancies, non-small cell lung cancer (NSCLC), and colorectal cancer .

Application

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Product Information

• Catalog No.: HY-175756
• CAS No.: 2901804-87-1
• Molecular Formula: C30H35N7O
• Molecular Weight: 509.65
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source