ALR2-IN-9

Overview

ALR2-IN-9 is a potent ALR2 inhibitor ( IC 50 = 21.8 nM) with excellent antioxidant activity ( EC 50 for DPPH radical scavenging = 2.8 μM). ALR2-IN-9 interacts directly with Reactive Oxygen Species ( ROS )/Reactive Nitrogen Species (RNS) and interrupts the free radical chain reactions, and as an endogenous enzymatic antioxidant regulator, which regulates enzyme functions of CAT and SOD . ALR2-IN-9 regulates PI3K / Akt / Nrf2 pathway to attenuate hyperglycemia-mediated mitochondrial superoxide overproduction in vitro, and ameliorates CuSO 4 - and H 2 O 2 -induced oxidative stress in vivo. ALR2-IN-9 prolongs lifespan of C. elegans via the regulation of stress response genes such as PMK-1 . ALR2-IN-9 is a promising anti-aging drug candidate. ALR2-IN-9 can be used for diabetic complication research.

Application

Products | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Metabolic Disease | Products > Signaling Pathways > PI3K | Products > Signaling Pathways > Akt | Products > Signaling Pathways > SOD | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Keap1-Nrf2 | Products > Signaling Pathways > Free Radical Scavengers | Products > Signaling Pathways > Aldose Reductase | Products > Signaling Pathways > Reactive Oxygen Species (ROS)

Product Information

• Catalog No.: HY-175862
• CAS No.: 2135481-84-2
• Molecular Formula: C25H28N4O6
• Molecular Weight: 480.51
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source