ADAM17-IN-1

Overview

ADAM17-IN-1 is a selective inhibitor of ADAM17 . ADAM17-IN-1 inhibits ADAM17 activity to reduce metabolic activity of dendritic cells (DCs), impair DC antigen-presenting function, suppress allergen-specific Th2 cell polarization, and reduce Th2 cytokine ( IL-4 , IL-5 , IL-13 ) secretion. ADAM17-IN-1 demonstrates protective efficacy against house dust mite (HDM)-induced type 2/eosinophilic airway inflammation in mice. ADAM17-IN-1 can be used for the study of type 2-high allergic asthma.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > MMP | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-175876
• CAS No.: 1802395-34-1
• Molecular Formula: C40H55N5O4
• Molecular Weight: 669.90
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source