MRL828

Overview

MRL828 is a heterobifunctional molecule that targets aggregated tau protein. As an autophagy-targeting chimera ( ATTEC ), MRL828 selectively labels aggregated tau protein for clearance via the autophagy ( autophagy )-lysosome pathway. The activity of MRL828 depends on autophagosomes rather than lysosomes, and it induces autophagosome-dependent secretion. MRL828 acts as an intracellular aggregate inhibitor and a secretory autophagy inducer , reducing intracellular levels of aggregated tau protein through autophagosome-dependent secretory autophagy instead of lysosomal degradation. MRL828 can be used in the research of neurodegenerative diseases such as Alzheimer's disease.

Application

Products | Products > Disease Areas > Alzheimer's Disease | Products > Disease Areas > Parkinson's Disease | Products > Disease Areas > Huntington's Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > ATTECs | Products > Signaling Pathways > Tau Protein | Products > Signaling Pathways > Autophagy

Product Information

• Catalog No.: HY-176130
• CAS No.: 3115333-82-6
• Molecular Formula: C46H51FN14O5S
• Molecular Weight: 931.05
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source