GPX4-AUTAC

Overview

GPX4-AUTAC is a GPX4 -targeting autophagy-mediated degrader ( AUTAC ). GPX4-AUTAC consists of an inhibitor ML162-yne ( HY-153748 ), a degradation tag FBnG ( HY-W073762 ) and a glycol linker ( HY-W021401 ). GPX4-AUTAC promotes the ubiquitination of GPX4 by E3 ligase TRAF6, and enhances the binding with GPX4 and p62 , leading to the selective autophagy-dependent degradation of GPX4. GPX4-AUTAC significantly induces ferroptosis and shows a potent anti-cancer activity in breast cancer cells, breast cancer-derived organoids (PDOs) and MDA-MB-231 tumor xenograft mice model, with potent synergistic effects when combined with Sulfasalazine (SAS) ( HY-14655 ) or chemotherapy drugs (Paclitaxel ( HY-B0015 ) or Cisplatin ( HY-17394 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > AUTACs | Products > Signaling Pathways > Autophagy | Products > Signaling Pathways > Glutathione Peroxidase | Products > Signaling Pathways > Ferroptosis

Product Information

• Catalog No.: HY-176220
• CAS No.: 3060458-90-1
• Molecular Formula: C50H55Cl2FN12O9S2
• Molecular Weight: 1122.08
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source