PROTAC MNK1 degrader-1

Overview

PROTAC MNK1 degrader-1 is a selective MNK1 PROTAC degrader with a DC 50 of 11.92 nM, and a D max > 96% in MV4-11 cells. PROTAC MNK1 degrader-1 significantly reduces p-eIF4E (IC 50 : 22.07 nM), induces apoptosis , and arrests the cell cycle at the G1 phase. PROTAC MNK1 degrader-1 has potent antitumor activity. PROTAC MNK1 degrader-1 has robust antileukemic efficacy in MV4-11 xenograft mice model with acceptable drug safety. (Pink: MNK1 ligand ( HY-176429 ); Blue: Cereblon ligand ( HY-A0003 ); Black: linker ( HY-Y1139 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Eukaryotic Initiation Factor (eIF) | Products > Signaling Pathways > MNK | Products > Signaling Pathways > PROTACs

Product Information

• Catalog No.: HY-176428
• CAS No.: 3120743-91-8
• Molecular Formula: C35H38N6O6S
• Molecular Weight: 670.78
• Purity: 98.93%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source