(R)-CDK2 degrader 6

Overview

(R)-CDK2 degrader 6 is the R-enantiomer of CDK2 degrader 6 ( HY-176444 ), a cereblon -based molecular glue degrader of CDK2 with a DC 50 of 27 nM. (R)-CDK2 degrader 6 induces ubiquitination and proteasomal degradation of CDK2 by bridging cereblon and CDK2 . (R)-CDK2 degrader 6 is applicable for cancer research.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Molecular Glues | Products > Signaling Pathways > CDK

Product Information

• Catalog No.: HY-176444A
• CAS No.: 3083777-50-5
• Molecular Formula: C23H22F5N5O3
• Molecular Weight: 511.44
• Purity: 99.55%
• Storage: -20°C, stored under nitrogen, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)
• Solubility: ≥ 2.5 mg/mL (4.89 mM); Clear solution
• Availability: In-stock

Source

Original product source