Mrgx2 antagonist-3

Overview

Mrgx2 antagonist-3 (Compound B-40) is a highly selective antagonist of MrgX2 receptor with an IC 50 value of 0.042-2.5 nM. Mrgx2 antagonist-3 blocks downstream G protein signaling and β-Arrestin recruitment, thereby inhibiting MrgX2 receptor-mediated calcium influx and cellular degranulation. Mrgx2 antagonist-3 is promising for research of inflammation-related diseases and pruritus, such as chronic urticaria, allergic asthma.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Mas-related G-protein-coupled Receptor (MRGPR)

Product Information

• Catalog No.: HY-176446
• CAS No.: 2641397-91-1
• Molecular Formula: C15H15F2N3O
• Molecular Weight: 291.30
• Purity: 98.24%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 0.4 mg/mL (1.37 mM); Clear solution
• Availability: In-stock

Source

Original product source