ZS3-046

Overview

ZS3-046 is a TAF1 PROTAC degrader. ZS3-046 promotes the ubiquitination and degradation of TAF1. ZS3-046 activates p53 and induces apoptosis in acute myeloid leukemia (AML) cells. ZS3-046 has antitumor activity in an AML tumor xenograft mouse model. (Pink: TAF1 ligand ( HY-176467 ); Blue: Cereblon ligand ( HY-41547 ); Black: linker ( HY-176469 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PROTAC | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > Small Interfering RNA (siRNA) | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > PROTACs

Product Information

• Catalog No.: HY-176457
• CAS No.: 3087879-97-5
• Molecular Formula: C49H57N9O7
• Molecular Weight: 884.03
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source