ST-899

Overview

ST-899 is a novel platelet-activating factor ( PAF ) receptor antagonist. ST-899 can significantly reduce the mortality of mice with endotoxin (LPS)-induced shock. ST-899 can significantly inhibit the increase in serum tumor necrosis factor (TNF) levels induced by LPS, but has no effect on interleukin-6 ( IL-6 ). The regulatory mechanism of ST-899 is to block the positive feedback loop between PAF and TNF, thereby reducing the inflammatory response. ST-899 can be used to study inflammatory diseases such as septic shock.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Platelet-activating Factor Receptor (PAFR) | Products > Signaling Pathways > TNF Receptor

Product Information

• Catalog No.: HY-176466
• CAS No.: 143484-41-7
• Molecular Formula: C22H29BrClNO6
• Molecular Weight: 518.83
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source