PROTAC pan-KRAS degrader-1

Overview

PROTAC pan-KRAS degrader-1 is a pan-KRAS PROTAC degrader for degrading different KRAS mutation types, such as G12D, G12C, G12V, and G13D. PROTAC pan-KRAS degrader-1 potently degrades KRAS mutation (G12D) in AGS cells, with a DC 50 of 1.1 nM, D max of 95%. PROTAC pan-KRAS degrader-1 can be used to search diseases caused by KRAS mutation or amplification, especially cancers such as breast cancer , bladder cancer , gastric cancer , etc. (Pink: pan-KRAS ligand ( HY-176490 ); Blue: VHL ligand ( HY-170353 ); Black: linker ( HY-176491 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-176489
• CAS No.: 3043908-63-7
• Molecular Formula: C63H71F2N13O7S
• Molecular Weight: 1192.38
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source