KBD4466

Overview

KBD4466 is an orally active potent TLR7 and TLR8 inhibitor with IC 50 s of 0.9 nM and 2.8 nM, respectively. KBD4466 inhibits the expression of inflammatory cytokines IL-6 and IFN-α . KBD4466 improves disease progression and survival in the BXSB/MpJ mouse model of Systemic Lupus Erythematosus (SLE). KBD4466 can be used in the study of autoimmune diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > Interleukin Related | Products > Signaling Pathways > IFNAR

Product Information

• Catalog No.: HY-176553
• CAS No.: 3023713-87-0
• Molecular Formula: C24H23F3N6O
• Molecular Weight: 468.47
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source