MCB-36

Overview

MCB-36 is a VHL-recruiting pan- KRAS PROTAC degrader without affecting KRAS transcription. MCB-36 exhibits minimal effects on HRAS and NRAS protein levels. MCB-36 binds to the GDP-loaded state of G12D, G12C, G12V, and wild-type KRAS with high affinities K d ≈ 1 pM). MCB-36 decreases p-ERK levels, leading to cell apoptosis . MCB-36 effectively suppress KRAS G12C inhibitor-resistant cancer cells and remodel the tumor immune microenvironment. MCB-36 can be used for the study of colorectal cancer and lung cancer (Pink: Target protein ligand; Blue: E3 ligand ( HY-112078 ); Black: Linker ( HY-W091879 )). (Pink: Target protein ligand; Blue: VHL ligand ( HY-112078 ); Black: linker ( HY-W091879 )).

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Lung Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PERK | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Caspase | Products > Signaling Pathways > TNF Receptor | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Ras | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-176786
• CAS No.: 3104382-00-2
• Molecular Formula: C60H71F2N9O7S
• Molecular Weight: 1100.32
• Purity: 98.43%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (2.27 mM); Clear solution
• Availability: In-stock

Source

Original product source