ACBI-4

Overview

ACBI-4 is a selective GTP -loaded active state of KRAS (KRAS(on)) PROTAC degrader, with K d values of 141 nM against KRAS G12R . ACBI-4 forms a stable ternary complex with VHL , triggering ubiquitination and KRAS degradation via the ubiquitin-proteasome system. ACBI-4 induces antiproliferative effects in KRAS mutant-driven cancer cells. ACBI-4 can be used for the research of KRAS mutant-driven cancer . (Pink: KRas G12R ligand ( HY-162960 ); Blue: VHL ligand ( HY-176917 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-176792
• CAS No.: 3097985-19-5
• Molecular Formula: C50H63N15O4S
• Molecular Weight: 970.20
• Purity: 98.01%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Availability: In-stock

Source

Original product source