(R)-ACBI-4

Overview

(R)-ACBI-4 is an isomer of ACBI-4 ( HY-176792 ). ACBI-4 is a selective GTP-loaded active state of KRAS (KRAS(on)) PROTAC degrader. ACBI-4 has significant anti-proliferative effect and potently degrades multiple KRAS mutants in cancer cells, such as KRASG12R. (Pink: Ras ligand ( HY-162960 ); Blue: VHL ligand ( HY-176917 ); Black: linker).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Others | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Ras | Products > Signaling Pathways > Drug Isomer

Product Information

• Catalog No.: HY-176792A
• CAS No.: 3097973-97-9
• Molecular Formula: C50H63N15O4S
• Molecular Weight: 970.20
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source