PROTAC SGK3 degrader-2

Overview

PROTAC SGK3 degrader-2 is the cis epimer of PROTAC SGK3 degrader-1 (SGK3-PROTAC1) ( HY-125878 ), with a cis hydroxyl group in its VH032 moiety, which is incapable of binding to the VHL E3 ligase . PROTAC SGK3 degrader-2 exhibits inhibitory activity against SGK3 , SGK1 , and S6K1 with IC 50 values of 0.6 μM, 1.4 μM, and 1.7 μM, respectively, but shows no SGK3 degradation efficiency. PROTAC SGK3 degrader-2 can be used as a control compound to study the specific effects of SGK3-PROTAC1-mediated SGK3 degradation. (Pink: SGK3 ligand ( HY-151009 ); Blue: VHL ligand ( HY-120217A ); Black: linker ( HY-130618 )).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > SGK

Product Information

• Catalog No.: HY-176823
• CAS No.: 2381196-78-5
• Molecular Formula: C57H73FN10O11S2
• Molecular Weight: 1157.38
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source