Rodin-A

Overview

Rodin-A is an orally active, brain-penetrant and selective histone deacetylase ( HDAC )-co-repressor of repressor element-1 silencing transcription factor ( CoREST ) complex inhibitor with an IC 50 value of 1.80 μM for the CoREST complex, 0.15 μM for HDAC1 , and 0.43 μM for HDAC2 . Rodin-A increases the acetylation level of histone H3K9, upregulates the expression of neuron-related genes, thereby promoting the increase in dendritic spine density, the colocalization of synaptic proteins (SV2A and PSD95), and the improvement of hippocampal long-term potentiation (LTP), exerting synaptic protection and repair activity. Rodin-A is promising for research of neurodegenerative diseases related to synaptic dysfunction, especially Alzheimer’s disease.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > HDAC

Product Information

• Catalog No.: HY-176866
• CAS No.: 2222756-46-7
• Molecular Formula: C17H16N6OS
• Molecular Weight: 352.41
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source