M119 (NSC 119910) is a selective Gβγ -subunit inhibitor. M119 selectively potentiates μ-opioid -dependent antinociception. M119 inhibits μ-receptor-dependent phospholipase ( PLC ) activation. M119 can enhance opioid analgesia and attenuate its acute tolerance and dependence in mice. M119 can be used for pain research.
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