HM5023507

Overview

HM5023507 is an orally active and selective PI3Kδ/γ inhibitor with IC 50 s of 4 and 5 μM for PI3Kδ and PI3Kγ over PI3Kβ and PI3Kα . HM5023507 attenuates the PI3Kδ/γ signaling in human basophils. HM5023507 also attenuates the activation and function of human B and T cells and cytokine and IgG production during cocultures, and Th17 differentiation of CD4 T cells. HM5023507 inhibited semiestablished collagen-induced arthritic inflammation in the rat models. HM5023507 can be used for inflammatory diseases like rheumatoid arthritis research.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > PI3K

Product Information

• Catalog No.: HY-177277
• CAS No.: 1549766-06-4
• Molecular Formula: C21H18ClN7O2
• Molecular Weight: 435.87
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source