M1 mAChR modulator-1 (Example 66) is a muscarinic M1 receptor ( mAChR1 ) positive allosteric modulator. M1 mAChR modulator-1 effectively promotes gastrointestinal motility and defecation in mouse models with low central permeability. M1 mAChR modulator-1 can be used for constipation research.
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