MeThPmR, a ribonucleoside derivative, is a potent and selective human nucleoside transporter 1 ( hCNT1 ) inhibitor ( K i/sub> = 0.16-0.69 μM). MeThPmR exhibit weak inhibitory activity on hCNT2 ( IC 50 = 360 μM) and hCNT3 ( K i = 4.7 μM). MeThPmR can protect cells from the toxicity of nucleoside drugs. MeThPmR can be used for the research of cancer .
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