MS99-β-Gal

Overview

MS99-β-Gal (Gal-MS99) is a galactose-modified NPM-ALK PROTAC degrader. MS99-β-Gal is only hydrolyzed by SA-β-gal and esterase in senescent cancer cells, releasing MS99, which specifically degrades the NPM-ALK fusion protein. MS99-β-Gal shows an IC 50 of 454.8 nM for aging Karpas 299 cells, significantly lower than that of normal Karpas 299 cells ( IC 50 = 2.162 μM). MS99-β-Gal can be used for the research of cancer . (Pink: NPM-ALK ligand ( HY-15656 ); Blue: VHL ligand ( HY-112078 ); Black: linker).

Application

Products | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > Anaplastic lymphoma kinase (ALK)

Product Information

• Catalog No.: HY-177945
• CAS No.: 3055593-63-7
• Molecular Formula: C78H96ClN9O20S2
• Molecular Weight: 1579.23
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source