H3R antagonist 8

Overview

H3R antagonist 8 is a selective nonimidazole histamine H3 receptor antagonist ( IC 50 = 0.35 μM). H3R antagonist 8 exhibits hERG channel blockade activity ( IC 50 = 0.67 μM). H3R antagonist 8 inhibits seizures by antagonizing H3 receptor. H3R antagonist 8 reduces tonic hind limb extension (THLE) in mice in the maximal electroshock seizure (MES) model ( ED 50 = 20.21 mg/kg) and and shortens pentylenetetrazol (PTZ)-induced total movement distance in AB strain zebrafish larvae. H3R antagonist 8 can be used for the study of epilepsy.

Application

Products | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Neurological Disease | Products > Signaling Pathways > Histamine Receptor

Product Information

• Catalog No.: HY-178016
• CAS No.: 3097193-89-7
• Molecular Formula: C23H27ClN2O2
• Molecular Weight: 398.93
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source