AHR agonist 10

Overview

AHR agonist 10 is a potent AHR agonist ( EC 50 = 2.01 nM). AHR agonist 10 can elevate the transcript levels of key AHR downstream pathway target genes, including CYP1A1 and CYP1B1 . AHR agonist 10 can downregulate the expression levels of CD36, IL-18 and shows low cytotoxicity (>40 μM) to normal cells. AHR agonist 10 can suppress the expression of CCL5, CCL20, IL-6 , IL-8 , S100A9, TLR4 , TNF-α, and TNFR1, demonstrating that AHR agonist 10 effectively modulate inflammatory responses through AHR dependent signaling pathways. AHR agonist 10 can be used for psoriasis research.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Aryl Hydrocarbon Receptor | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-178053
• CAS No.: 1191937-43-5
• Molecular Formula: C18H20O3
• Molecular Weight: 284.35
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source