MRL-SYKi

Overview

MRL-SYKi is a chemical probe for gain-of-function variants of spleen tyrosine kinase ( SYK ). MRL-SYKi reduces the catalytic activity of SYK S550Y , SYK S550F and SYK P342T , and downregulates the phosphorylation level of SYK S550Y . MRL-SYKi serves as a template for developing NanoBRET tracers targeting SYK , enabling NanoBRET cellular target engagement assays for gain-of-function variants of SYK . MRL-SYKi is applicable to research related to inflammatory and immune diseases.

Application

Products | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Syk

Product Information

• Catalog No.: HY-178129
• CAS No.: 1312534-69-2
• Molecular Formula: C24H28N4O3S
• Molecular Weight: 452.57
• Purity: 98.97%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source