EVT-401

Overview

EVT-401 is an orally active, potent and highly selective human P2X7R antagonist, with an IC 50 of 10 nM and a K i of 7.6 nM for human P2X7R, and an IC 50 of 220 nM for mouse P2X7R. EVT-401 promotes apoptosis and induces cell cycle arrest in human rheumatoid arthritis synovial fibroblasts (RA SF), reduces the production of proinflammatory and joint-destructive mediators, and mitigates aggressive phenotypes. EVT-401 exhibits favorable oral bioavailability and a good safety profile, making it suitable for research into rheumatoid arthritis.

Application

Products | Products > Disease Areas > Rheumatoid Arthritis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > P2X Receptor | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-178230
• CAS No.: 951015-69-3
• Molecular Formula: C22H20F4N2O3
• Molecular Weight: 436.40
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source