LY237

Overview

LY237 is a potent GPR84 full agonist, with EC 50 values of 0.189 nM and 0.07 nM in cAMP inhibition assay and calcium flux assay, respectively. LY237 binds to the amphipathic orthosteric pocket of GPR84 , stabilizes the active conformation of the receptor, and promotes its coupling with Gαi protein. LY237 can be used in research related to ulcerative colitis, fibrotic diseases, non-alcoholic steatohepatitis, and acute respiratory distress syndrome.

Application

Products | Products > Disease Areas > Ulcerative Colitis | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Peptic Ulcer Disease | Products > Disease Areas > Digestive System Inflammation | Products > Signaling Pathways > GPCR/G Protein | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > GPR84

Product Information

• Catalog No.: HY-178234
• CAS No.: 1892576-07-6
• Molecular Formula: C14H23NO2
• Molecular Weight: 237.34
• Purity: 99.96%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source