PROTAC EGFR degrader 16

Overview

PROTAC EGFR degrader 16 (Compound 98) a selective EGFR PROTAC degrader with DC 50 values of < 50 nM in NCI-H1975 ( EGFR L858R-T970M ), NCI-H3225 ( EGFR L858R ) and NCI-H1976 + CS ( EGFR L858R-T970M-L797S ). PROTAC EGFR degrader 16 can be used for the study of EGFR-driven cancerssuch as non-small cell lung cancer (Pink: EGFR ligand ( HY-178313 ); Blue: CRBN ligand (HY-W1128702); Black: Linker; EGFR ligand + Linker ( HY-178311 )). (Pink: EGFR ligand ( HY-178313 ); Blue: Ligands for E3 Ligase E3 ligase ligand; Black: linker).

Application

Products | Products > Signaling Pathways > PROTAC | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > PROTACs | Products > Signaling Pathways > EGFR

Product Information

• Catalog No.: HY-178242
• CAS No.: 2654821-07-3
• Molecular Formula: C48H48F2N10O6S
• Molecular Weight: 931.02
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source